Autologous
(autologous
refers to
cells, tissues or even
growth factors
that are re-implanted in the same individual as they come from,
another words patient receives his or her own cells) cell therapy injections is a by-product of blood that is rich in
Growth factors and platelets. Until now, its use has been confined to the hospital
setting. This was due mainly to the cost of separating the cells
from the blood and the large amount of blood needed to produce a
suitable quantity of cells. New technology permits the doctor to
harvest and produce a sufficient quantity of cells from only 30-50
cc of blood drawn from the patient while they are in the office
setting. It takes about 20 minutes to harvest these cells prior to
injection.
These cells allow the body to take advantage of the
normal healing pathways at a greatly accelerated rate. During the
healing process, the body rushes many cells and cell-types to the
injected area in order to accelerate the healing process. These
cells perform many functions,
including release of growth factors (GF) into the diseased or
arthritic and injured sites. Another main function is attracting
Mesenchymal Stem Cells to the damaged area. These Growth
factors (Vascular Endothelial Growth Factor VEGF1, Platelet Derived Growth
Factors PDGF, Insulin-Like Growth Factor ILGF and Transforming
Growth Factor Beta TGF) function to assist the body in repairing
itself by stimulating stem cells to regenerate new tissue. The more
growth factors released sequestered into the damaged cells, the more
stem cells stimulated to produce new host tissue. Thus, one can
easily see that Cell Therapy and its applications for injection in to the
Joints and Tendons to improve osteoarthritis
and sports injuries. Currently Cell Therapy has been used for pain and
arthritis of Knee, Shoulder, Spine, Hip, Ankle, Wrist and Elbow at
The Center For Regenerative Medicine.
A
subfamily of these cells , are Mesenchymal Stem cells. The MSC (these
stem cells are different from the embryonic stem cells. These
stem cells are contained within each individual and are derived from
patient self) have been shown to
be multipotent, having potential of becoming ,Cardiac , Nerve, Hepatocytes (liver cells), Chondrocytes (cartilage
cells) , as well as Vascular cells (angiogenesis). Angiogenesis is of great
significance to the Orthopedic Regenerative physician whose goal is improvement of arthritis and sports injuries.
|