PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus) This term is used to describe a subset of children who have Obsessive Compulsive Disorder (OCD) and/or tic disorders such as Tourette Syndrome, and in whom symptoms worsen following strep infections such as “Strep throat” and Scarlet Fever. The children usually have dramatic, “overnight” onset of symptoms, including motor or vocal tics, obsessions, and/or compulsions. In addition to these symptoms, children may also become moody, irritable or show concerns about separating from parents or loved ones. This abrupt onset is generally preceded by a Strep throat infection. Researchers at the NIMH are pursuing a theory that the mechanism or cause is similar to that of Rheumatic Fever, an autoimmune disorder triggered by strep throat infections.