Primary sclerosing cholangitis refers to swelling (inflammation), scarring, and destruction of the bile ducts inside and outside of the liver. The cause of this condition is usually unknown. The disease may be seen in patients who have: autoimmune disorders, chronic pancreatitis, inflammatory bowel disease (Crohn’s disease and ulcerative colitis), and sarcoidosis. Genetic factors may also be responsible. Sclerosing cholangitis occurs more often in men than women. This disorder is rare in children. The first symptoms are usually: fatigue, itching, and yellowing of the skin and eyes (jaundice). However, some people may have no symptoms. How well patients do varies. The disease tends to get worse over time.